Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9314
Gene Symbol: KLF4
KLF4 		0.010 Biomarker disease BEFREE Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network. 31623405 2019
Entrez Id: 4629
Gene Symbol: MYH11
MYH11 		0.030 GeneticVariation disease BEFREE A new Variant in the MYH11 gene in a Familial case of Thoracic Aortic Aneurysm. 31473177 2020
Entrez Id: 693159
Gene Symbol: MIR574
MIR574 		0.010 Biomarker disease BEFREE MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm. 31409059 2019
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.020 Biomarker disease BEFREE Background Thoracic aortic aneurysm ( TAA ) and dissection ( TAD ) are characterized by progressive disorganization of the aortic wall matrix, including elastin, a highly immunogenic molecule. 30957625 2019
Entrez Id: 59
Gene Symbol: ACTA2
ACTA2 		0.430 GeneticVariation disease BEFREE Novel variants in the ACTA2 and MYH11 genes in a Cypriot family with thoracic aortic aneurysms: a case report. 30526509 2018
Entrez Id: 4629
Gene Symbol: MYH11
MYH11 		0.030 GeneticVariation disease BEFREE Novel variants in the ACTA2 and MYH11 genes in a Cypriot family with thoracic aortic aneurysms: a case report. 30526509 2018
Entrez Id: 54538
Gene Symbol: ROBO4
ROBO4 		0.300 Biomarker disease CTD_human ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. 30455415 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.510 AlteredExpression disease BEFREE However, few studies have assessed serum MMP9 levels in both abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA). 30373522 2018
Entrez Id: 7057
Gene Symbol: THBS1
THBS1 		0.010 Biomarker disease BEFREE Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans. 30355232 2018
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.460 GeneticVariation disease BEFREE Three Novel Mutations in FBN1 and TGFBR2 in Patients with the Syndromic Form of Thoracic Aortic Aneurysms and Dissections. 30101859 2018
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		0.330 GeneticVariation disease BEFREE Three Novel Mutations in FBN1 and TGFBR2 in Patients with the Syndromic Form of Thoracic Aortic Aneurysms and Dissections. 30101859 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 AlteredExpression disease BEFREE Blood and tissue homogenized levels of IL-6 and TNF-α were significantly higher in the AD group than in the AA group (p<0.001). 30088482 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.010 AlteredExpression disease BEFREE Blood and tissue homogenized levels of IL-6 and TNF-α were significantly higher in the AD group than in the AA group (p<0.001). 30088482 2018
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17 		0.210 Biomarker disease BEFREE Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm. 29930147 2018
Entrez Id: 49
Gene Symbol: ACR
ACR 		0.010 Biomarker disease BEFREE ACR Appropriateness Criteria<sup>®</sup> Suspected Thoracic Aortic Aneurysm. 29724424 2018
Entrez Id: 4054
Gene Symbol: LTBP3
LTBP3 		0.010 GeneticVariation disease BEFREE LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections. 29625025 2018
Entrez Id: 4638
Gene Symbol: MYLK
MYLK 		0.010 GeneticVariation disease BEFREE Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype. 29544503 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.020 Biomarker disease BEFREE MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling. 29519942 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.010 Biomarker disease BEFREE MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling. 29519942 2018
Entrez Id: 2316
Gene Symbol: FLNA
FLNA 		0.010 GeneticVariation disease BEFREE Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations. 29334594 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.020 Biomarker disease BEFREE Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice. 29197606 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 AlteredExpression disease BEFREE Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation. 28791384 2017
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.010 Biomarker disease BEFREE Long Non-coding RNA-mRNA Correlation Analysis Reveals the Potential Role of HOTAIR in Pathogenesis of Sporadic Thoracic Aortic Aneurysm. 28757056 2017
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.020 Biomarker disease BEFREE SMAD4 is as an essential mediator of the transforming growth factor β (TGF-β) signaling pathway, and dysregulated TGF-β signaling is linked with thoracic aortic aneurysms (TAAs). 28716708 2017
Entrez Id: 93663
Gene Symbol: ARHGAP18
ARHGAP18 		0.010 Biomarker disease BEFREE ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype. 28701309 2017